Multiplicación de especies silvestres mediterráneas para uso ornamental

Peer Reviewe

Transition from the old to the new viral normality: Where are we?

Background: The seasonality of respiratory diseases caused by viruses has been altered by the emergence of SARS-CoV-2. After a period of almost no bronchiolitis and influenza diagnoses, these seasonal infectious diseases are progressively recovering their pre-pandemic dynamics. We aim to describe how this process is taking place in Catalonia. Material and method: We used primary-care syndromic diagnostic data of bronchiolitis, influenza, and COVID-19 in Catalonia (Spain), which are publicly available through the new Information System for the Surveillance of Infections in Catalonia (SIVIC). We carried out a descriptive study of their dynamics from 2014 to 2023, focusing on the changes induced by the pandemic. Results: The results show that the old viral normality was significantly disrupted by SARS-CoV-2 and that we are experiencing a transition to a new viral normality where this novel infectious agent could play a role, but its precise dynamics remains unclear. Conclusions: We are slowly moving towards regular influenza and bronchiolitis seasonality. The role of SARS- CoV-2 in the viral landscape in Catalonia remains uncertain, but its effects on other pathogens are relevant and warrant further investigation.Peer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarPostprint (published version

INDISIM-YEAST, an individual-based model to study yeast

INDISIM-YEAST, an individual-based simulator, models the evolution of a yeast population by setting up rules of behaviour for each individual cell according to their own biological rules and characteristics. It takes into account the uptake, metabolism, budding reproduction and viability of the yeast cells, over a period of time in the bulk of a liquid medium, occupying a three dimensional closed spatial grid with two kinds of particles (glucose and ethanol). Each microorganism is characterized by its biomass, genealogical age, states in the budding cellular reproduction cycle and position in the space among others. Simulations are carried out for population properties (global properties), as well as for those properties that pertain to individual yeast cells (microscopic properties). The results of the simulations are in good qualitative agreement with established experimental trends.Peer Reviewe

Àfrica, Universitat Politècnica de Catalunya i cooperació al desenvolupament: 15 anys d'història, 15 anys d'aprenentatge

En aquest document es pretén revisar una part del treball realitzat pel CCD. En concret, s’analitzen les accions desenvolupades a l’Àfrica que, si bé comencen a integrar un bagatge considerable, encara tenen un pes menor en el conjunt d’iniciatives de cooperació impulsades des del CCD.Peer Reviewe

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3

CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to TLR activation. In the present study, we questioned whether CD5L is able to influence human macrophage plasticity, and drive its polarization toward any specific phenotype. We compared CD5L-induced phenotypic and functional changes to those caused by IFN/LPS, IL4, and IL10 in human monocytes. Phenotypic markers were quantified by RT-qPCR and flow cytometry, and a mathematical algorithm was built for their analysis. Moreover, we compared ROS production, phagocytic capacity, and inflammatory responses to LPS. CD5L drove cells toward a polarization similar to that induced by IL10. Furthermore, IL10- and CD5L-treated macrophages showed increased LC3-II content and colocalization with acidic compartments, thereby pointing to the enhancement of autophagy-dependent processes. Accordingly, siRNA targeting ATG7 in THP1 cells blocked CD5L-induced CD163 and Mer tyrosine kinase mRNA and efferocytosis. In these cells, gene expression profiling and validation indicated the upregulation of the transcription factor ID3 by CD5L through ATG7. In agreement, ID3 silencing reversed polarization by CD5L. Our data point to a significant contribution of CD5L-mediated autophagy to the induction of ID3 and provide the first evidence that CD5L drives macrophage polarization.Peer ReviewedPostprint (published version

Dades i comunicació en temps de pandèmia

Peer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarPostprint (published version

La ciència al servei de la lluita contra la Covid-19

Investigadors del Campus del Baix Llobregat de la UPC treballen amb models matemàtics per estudiar la dinàmica de la malaltia. Els científics aconsegueixen fer prediccions de com evolucionarà la infecció de tres a cinc dies i, de moment, estan funcionant.Diari El LlobregatPostprint (published version

To achieve an earlier IFN-¿ response is not sufficient to control mycobacterium tuberculosis infection in mice

The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-c response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-c response, and that control of the BL is not immediate after onset of the IFN-c response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-c response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.Peer ReviewedPostprint (published version